Discussion Question Assignment Example | Topics and Well Written Essays - 250 words - 15

Discussion Question - Assignment Example public health is the prevention, cure, and control of infectious diseases, improved sanitation, and reduced incidences of cholera, typhoid, tuberculosis, and sexually transmitted diseases (Novick, Morrow, & Mays, 2008). All these public health components are accounted for by the fifth great public health achievement in the textbook. This achievement has gone a long way in transforming the face of the contemporary society. Preventative and curative measures are in place to manage, control, and oversee public health development. On the same note, improved sanitation translates to a better quality of life. When the society leads a healthy life, there is less likelihood of public health crisis. This achievement, therefore, averts public health crisis by empowering the society to take control of its welfare. In conclusion, the above achievement is great because it accounts for the most basic components of a healthy society. Food, water, and shelter are influential as far as public health is concerned. With improved sanitation and reduced disease incidences in the society, people’s overall lifestyles exhibit high quality practices. This is undoubtedly a great achievement in the public health

News conference case studies Study Example | Topics and Well Written Essays - 500 words

News conference studies - Case Study Example Additionally, the company has a long-term perspective of its investments. It focuses its resources and efforts towards the creation of value through superior performance and growth. This background of Najafi Companies motivated Chef Paula Deen to seek the firm’s assistance in her comeback. Her former employee faced Chef Paula Deen with a number of challenges following the allegations. As a result, she lost her cooking show and lucrative endorsement deals. Additionally, she was forced to close down her restaurant. In the process of exploring her future, and position in the industry, Chef Deen identified Najafi Companies as an important investment partner. Chef Deen intends to build on Najafi Companies strong brand presence and heritage as part of her transformation (Najafi Companies 1). Therefore, Chef Paula Deen and Najafi Companies would like to announce their partnership and the launch of Deen’s debut cooking show, product launch and book deals. The essence of the new partnership is based on mutual partnership. Najafi Companies has invested $75 million in the new Paula Deen Ventures. The venture will be responsible for the debut of new cooking shows, product and book deals. The essence of the new partnership captures the nature of Paula Deen as a resilient person. It also outlines the nature of Najafi Companies as a company that is willing to invest in struggling groups, people, entities and businesses (Najafi Companies 1). Therefore, Paula Deen’s customers, business partners and audiences should expect a positive experience from the new venture. The new venture is a milestone for Paula Deen. Today’s announcement is a renewal of Deen’s promise to her audience and customers. Paula Deen intends to focus all her efforts and resources towards the satisfaction of her customers. The partnership between Paula Deen and Najafi Companies is three fold. First, customers will have an easier time to

The Significance of HER 2 Receptor Expression in Breast Cancer Tissue Essay

The Significance of HER 2 Receptor Expression in Breast Cancer Tissue - Essay Example It has been found that up to 25% of breast cancer patients will have an amplification of the HER2/neu gene or an increase in HER2 production (Songdong et al, 2006). Additionally, any patient with amplification of this gene will generally have an increased likelihood of cancer recurrence and a more aggressive form of cancer (Meng et al, 2004). The purpose of this paper is to discuss further the significance of HER2 receptor expression in breast cancers, and describe the laboratory methods of detecting this protein in detail. This will give an overview of the complications of overexpression of HER2 and allow the reader an insight into how important the HER2 protein and the HER2/neu gene are in breast cancers and how the detection of these can allow for insight into breast cancer and can lead to a reduction in the number of fatalities from breast cancer. Significance of HER2 in Breast Cancers The significance of the HER2 protein in breast cancers has been widely discussed in the literat ure. As previously mentioned, 'Overexpression of urokinase plasminogen activator system or HER-2 (erbB-2) in breast cancer is associated with a poor prognosis' (Songdong et al, 2006, p17361). ... ding two cysteine rich domains, a transmembrane domain, and an intracellular domain, consisting of a juxtamembrane region, a tyrosine kinase domain, and a carboxyl tail harboring autophosphorylation sites' (Brennan, 2002, p328). It is the binding of certain cognate cofactors to this trans-membrane receptor that regulates cell growth and differentiation, which occurs through the activation of receptor tyrosine kinases (Brennan, 2002). This is a type of signal transduction pathway, which in the case of HER2 involves ogliomerization (Meng et al, 2004) and dimerization (Brennan, 2002). On a study of rats by Bargmann et al (1986), it was found that the neu gene (which is classed as protooncogene) is converted to the aggressive oncogene associated with overproduction of HER2 by a single point mutation at position 664 of the protein sequence. This mutation is from a valine to the negatively-charged glutamate, and is associated with an increase of the liklihood that the receptor will form ag gregates. Unfortunately, the mutation at position 664 is not found in humans, but this has given clues as to the mechanism of the HER2 protein in causing the more aggressive forms of breast cancers. `Figure 1 shows the pathway that HER2 plays a role in within the confines of breast cancer. Figure 1 – Cross-talk between signal transduction pathways and ER signaling in endocrine resistant breast cancer, with opportunities for targeted intervention (Ellis & Ma, 2007, p107) An insight into these pathways allows for recognition of interventions that can be used to negate the effects of the increased production of HER2. From figure 1, it is evident that HER2 is surface-membrane protein with a critical role in the MAPK/ERK signal transduction pathway. The MAPK/ERK pathway passes a signal from

Protestantism and Catholicism Essay Example | Topics and Well Written Essays - 1500 words

Protestantism and Catholicism - Essay Example Other significant concerns expressed by Martin Luther entailed the notion that there were fundamental ideological differences between the religious truths as Martin Luther saw it and the doctrine of the Catholic Church. These differences included the notion of purgatory, particular judgment, devotion to Mary, the intercession of the saints, most of the sacraments, and the authority of the Pope.1 These ideological differences led to a split within the Catholic Church. This split effectively led to the creation of the Protestant Church as well as a difference in the way in which both churches set out to negotiate with the popular culture of the time. This paper will focus on these differences and illuminate the underlying causes of contention. First and foremost, in order to conceptualize the difference between Catholicism and Protestantism with regards to the negotiation of popular culture it is prudent that we discuss the basic tenets of the two religions. Most importantly, the fundamental religious beliefs of Catholics are those that have been derived from the New Testament and are symbolized through the many sacraments. The most fundamental belief is one that entails the notion that there is a holy trinity and the deity consists of three divine persons-God the father, the son and the Holy Ghost.2 Within the Catholic Church there is a central belief that God came into being as a direct result of the incarnation of his Son. Within the Catholic tradition there is an emphasis on sacraments. Essentially, there are seven sacraments. These sacraments include Baptism, Eucharist, Reconciliation, Confirmation, Marriage, Holy Orders and Anointing of the Sick. The Sacraments are essentially ceremonies which highlight what is impo rtant, sacred and significant in the lives of Catholics. Of these sacraments, the Baptism and the Eucharist have special prominence in that the Baptism is the sacramental entry into religious life for Catholics and the Eucharist is the symbolic memorial of the death and subsequent resurrection of Christ. Another important sacrament is that of the Reconciliation wherein Catholics are given absolution from their sins through the process of confession.3 The Protestant Reformation era represents a split within the Catholic Church and the emergence of the Protestant Church as a corrective action for dealing with what Martin Luther and other reformists felt were inherent flaws within Christianity. First and foremost, the official start of the reformation can be seen in 1517 when Martin Luther, an ex-communicated monk, produced his ninety-five theses which delineated his repugnance at the fact that there was a systematic abuse of papal power. This abuse was most evident in the sale of indulgences by Pope Leo X as a means of raising funds for the construction of the St. Peter's Basilica in Rome.4 This action served to infuriate an already furious Martin Luther who was essentially appalled at the fact that the powers afforded the Pope continued to expand and had become such that the Catholic Church not only asserted its influence on the mundane existence of its constituents but its influence was now evident in the determination of the qua lity of after-life afforded to believers. Essentially, his main contention involved the fact that faith had taken a diminished role while good acts were given a more prominent role. The notion of one buying his/her way into heaven was one that disturbed Luther who

THE NATURE AND SIGNIFICANCE OF THE NEW TESTAMENT Essay - 1

THE NATURE AND SIGNIFICANCE OF THE NEW TESTAMENT - Essay Example Through such a level of engagement understanding, it is the hope of this author that the reader will gain a more informed and relevant understanding as to why the New Testament exists, how it came to be, and what overall relevance this has to the believer/nonbeliever within the current time. Firstly, in seeking to answer the question of what defines the Old Testament, the reader can and should engage with the understanding that it is far more than a mere continuation of the books of the Old Testament. Instead, it is the direct fulfillment of prophecy that was alluded to from the book of Genesis; when God promised that the circuit would be dealt a mortal wound. Naturally, this mortal wound was with reference to the fact that price, God’s own son, would come to the earth and serve as atonement for the sins of all mankind. This particular theme of salvation, atonement, and a savior is represented throughout the Old Testament and a litany of different prophecies and levels of foreshadowing. In such a way, rather than merely interpreting the New Testament as a continuation of doctrine and religious belief, the individual should approach it as the fulfillment of ancient prophecy and the proof that the prior Scriptures had come to be fulfilled. As compared to the Old Testament, the New Testament was written in a relatively short period of time; approximately 50 years. As a result of the fact that the early churches received the writings of the apostles, they began to be distributed, copied, and studied by these early groups of Christians. This naturally led the entire process to one in which the early church fathers, including Clement, Polycarp, and Ignatius, began to readily combine and distribute all of these as a means of providing a thorough overview of the way in which doctrine, belief, and understanding be represented among the early believers. Not surprisingly, a great deal of controversy arose with respect to what should be included and what should not.

The Significance of HER 2 Receptor Expression in Breast Cancer Tissue Essay

The Significance of HER 2 Receptor Expression in Breast Cancer Tissue - Essay Example It has been found that up to 25% of breast cancer patients will have an amplification of the HER2/neu gene or an increase in HER2 production (Songdong et al, 2006). Additionally, any patient with amplification of this gene will generally have an increased likelihood of cancer recurrence and a more aggressive form of cancer (Meng et al, 2004). The purpose of this paper is to discuss further the significance of HER2 receptor expression in breast cancers, and describe the laboratory methods of detecting this protein in detail. This will give an overview of the complications of overexpression of HER2 and allow the reader an insight into how important the HER2 protein and the HER2/neu gene are in breast cancers and how the detection of these can allow for insight into breast cancer and can lead to a reduction in the number of fatalities from breast cancer. Significance of HER2 in Breast Cancers The significance of the HER2 protein in breast cancers has been widely discussed in the literat ure. As previously mentioned, 'Overexpression of urokinase plasminogen activator system or HER-2 (erbB-2) in breast cancer is associated with a poor prognosis' (Songdong et al, 2006, p17361). ... ding two cysteine rich domains, a transmembrane domain, and an intracellular domain, consisting of a juxtamembrane region, a tyrosine kinase domain, and a carboxyl tail harboring autophosphorylation sites' (Brennan, 2002, p328). It is the binding of certain cognate cofactors to this trans-membrane receptor that regulates cell growth and differentiation, which occurs through the activation of receptor tyrosine kinases (Brennan, 2002). This is a type of signal transduction pathway, which in the case of HER2 involves ogliomerization (Meng et al, 2004) and dimerization (Brennan, 2002). On a study of rats by Bargmann et al (1986), it was found that the neu gene (which is classed as protooncogene) is converted to the aggressive oncogene associated with overproduction of HER2 by a single point mutation at position 664 of the protein sequence. This mutation is from a valine to the negatively-charged glutamate, and is associated with an increase of the liklihood that the receptor will form ag gregates. Unfortunately, the mutation at position 664 is not found in humans, but this has given clues as to the mechanism of the HER2 protein in causing the more aggressive forms of breast cancers. `Figure 1 shows the pathway that HER2 plays a role in within the confines of breast cancer. Figure 1 – Cross-talk between signal transduction pathways and ER signaling in endocrine resistant breast cancer, with opportunities for targeted intervention (Ellis & Ma, 2007, p107) An insight into these pathways allows for recognition of interventions that can be used to negate the effects of the increased production of HER2. From figure 1, it is evident that HER2 is surface-membrane protein with a critical role in the MAPK/ERK signal transduction pathway. The MAPK/ERK pathway passes a signal from

THE NATURE AND SIGNIFICANCE OF THE NEW TESTAMENT Essay - 1

THE NATURE AND SIGNIFICANCE OF THE NEW TESTAMENT - Essay Example Through such a level of engagement understanding, it is the hope of this author that the reader will gain a more informed and relevant understanding as to why the New Testament exists, how it came to be, and what overall relevance this has to the believer/nonbeliever within the current time. Firstly, in seeking to answer the question of what defines the Old Testament, the reader can and should engage with the understanding that it is far more than a mere continuation of the books of the Old Testament. Instead, it is the direct fulfillment of prophecy that was alluded to from the book of Genesis; when God promised that the circuit would be dealt a mortal wound. Naturally, this mortal wound was with reference to the fact that price, God’s own son, would come to the earth and serve as atonement for the sins of all mankind. This particular theme of salvation, atonement, and a savior is represented throughout the Old Testament and a litany of different prophecies and levels of foreshadowing. In such a way, rather than merely interpreting the New Testament as a continuation of doctrine and religious belief, the individual should approach it as the fulfillment of ancient prophecy and the proof that the prior Scriptures had come to be fulfilled. As compared to the Old Testament, the New Testament was written in a relatively short period of time; approximately 50 years. As a result of the fact that the early churches received the writings of the apostles, they began to be distributed, copied, and studied by these early groups of Christians. This naturally led the entire process to one in which the early church fathers, including Clement, Polycarp, and Ignatius, began to readily combine and distribute all of these as a means of providing a thorough overview of the way in which doctrine, belief, and understanding be represented among the early believers. Not surprisingly, a great deal of controversy arose with respect to what should be included and what should not.